The API provides a wide range of detailed disease information, facilitating access to key data for medical analysis and applications. From specific related genes to genetic variants and associated phenotypes, this API becomes an invaluable tool for understanding and addressing various medical conditions.
At its core, the API provides access to comprehensive disease data, enabling the querying of information such as genes linked to a particular disease, genetic variants identified in association with the condition, and relevant clinical phenotypes. This information is essential for researchers studying the genetic basis of diseases, as it provides detailed insight into how certain genes and their variants may influence predisposition to or development of a specific disease.
A highlight of the API is its ability to easily integrate with existing applications and systems in healthcare and biomedical research. This allows developers to create custom tools that use the API data to improve the diagnosis, treatment and understanding of complex diseases.
In short, the API not only provides access to detailed and accurate data on diseases, genes and genetic variants, but also stands out for its ability to support scientific research, medical innovation and continuous improvement of evidence-based healthcare. Its versatility and robustness make it an essential tool in the arsenal of any practitioner or researcher seeking to understand and address the complexities of disease from an advanced genomic and clinical perspective.
It will receive a parameter and provide you with a JSON.
Besides the number of API calls, there is no other limitation.
To use this endpoint you must indicate the name of a disease in the parameter.
Disease - Endpoint Features
| Object | Description |
|---|---|
q |
[Required] |
{"took":16,"total":724,"max_score":7.9725885,"hits":[{"_id":"MONDO:0011361","_score":7.9725885,"ctd":{"omim":"603688","pathway_related_to_disease":[{"inference_gene_symbol":"EPHB2","kegg_pathway_id":"hsa04360","pathway_name":"Axon guidance","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPH-Ephrin signaling","react_pathway_id":"R-HSA-2682334","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"L1CAM interactions","react_pathway_id":"R-HSA-373760","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPHB-mediated forward signaling","react_pathway_id":"R-HSA-3928662","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Ephrin signaling","react_pathway_id":"R-HSA-3928664","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPH-ephrin mediated repulsion of cells","react_pathway_id":"R-HSA-3928665","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Axon guidance","react_pathway_id":"R-HSA-422475","source":"CTD"}]},"disgenet":{"_license":"https://creativecommons.org/licenses/by/4.0/","genes_related_to_disease":[{"DPI":0.846,"DSI":0.374,"gene_id":2048,"gene_name":"EPHB2","score":0.4,"source":"CLINVAR"},{"DPI":0.846,"DSI":0.374,"gene_id":2048,"gene_name":"EPHB2","score":0.4,"source":"CTD_human"}],"variants_related_to_disease":[{"DSI":1.0,"chrom":"1","pos":22907980,"rsid":"rs121912582","score":0.7,"source":"CLINVAR"},{"DPI":0.08,"DSI":0.882,"chrom":"1","pos":22913757,"rsid":"rs76826147","score":0.7,"source":"CLINVAR"}],"xrefs":{"disease_name":"PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding)","mondo":"MONDO:0011361","omim":"603688","umls":"C1863600"}},"hpo":{"disease_name":"Prostate cancer/brain cancer susceptibility","omim":"603688","phenotype_related_to_disease":[{"biocuration":{"date":"2013-01-14","name":"HPO:skoehler"},"evidence":"IEA","hpo_id":"HP:0100006","omim_refs":"OMIM:603688","original_disease_id":"OMIM:603688"},{"biocuration":{"date":"2013-01-09","name":"HPO:skoehler"},"evidence":"IEA","hpo_id":"HP:0012125","omim_refs":"OMIM:603688","original_disease_id":"OMIM:603688"}]},"mondo":{"ancestors":["MONDO:0003847","MONDO:0020573","MONDO:0023370","MONDO:0021058","MONDO:0700096","MONDO:0002254","MONDO:0045024","MONDO:0042489","MONDO:0015356","MONDO:0000001"],"excluded_subClassOf":{"mondo":["MONDO:0008315"]},"has_material_basis_in_germline_mutation_in":{"http":["http://identifiers.org/hgnc/3393"]},"label":"prostate cancer/brain cancer susceptibility","mondo":"MONDO:0011361","parents":["MONDO:0015356"],"predisposes_towards":{"mondo":["MONDO:0001657"]},"synonym":{"exact":["prostate cancer/brain cancer susceptibility","prostate cancer/brain cancer susceptibility, somatic"],"related":["Capb","Pcbc"]},"xrefs":{"medgen":["400334"],"omim":["603688"],"umls":["C1863600"]}}},{"_id":"MONDO:0018502","_score":7.36427,"mondo":{"ancestors":["MONDO:0005070","MONDO:0021223","MONDO:0700096","MONDO:0001056","MONDO:0004992","MONDO:0021085","MONDO:0005626","MONDO:0003847","MONDO:0004335","MONDO:0045024","MONDO:0002516","MONDO:0004950","MONDO:0004993","MONDO:0023370","MONDO:0004298","MONDO:0000001","MONDO:0006181"],"children":["MONDO:0006226","MONDO:0007648","MONDO:0017790","MONDO:0100256"],"definition":"Hereditary gastric cancer refers to the occurrence of gastric cancer in a familial context and is described as two or more cases of gastric cancer in first or second degree relatives with at least one case diagnosed before the age of 50. Familial clustering is observed in 10% of all cases of gastric cancer, and includes hereditary diffuse gastric cancer (early onset diffuse-type gastric cancer), gastric adenocarcinoma and proximal polyposis of the stomach and familial intestinal gastric cancer (familial clustering of intestinal type gastric adenocarcinoma). Hereditary gastric cancer can also occur in other hereditary cancer syndromes such as Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis and juvenile polyposis syndrome. [Orphanet:423776]","descendants":["MONDO:0100256","MONDO:0017790","MONDO:0007648","MONDO:0006226"],"label":"hereditary gastric cancer","mondo":"MONDO:0018502","parents":["MONDO:0003847","MONDO:0004950"],"synonym":{"exact":["hereditary cancer of stomach","hereditary gastric cancer"]},"xrefs":{"gard":["21758"],"medgen":["1843054"],"orphanet":["423776"],"umls":["C5680075"]}}},{"_id":"MONDO:0001060","_score":7.269791,"disease_ontology":{"_license":"https://github.com/DiseaseOntology/HumanDiseaseOntology/blob/master/DO_LICENSE.txt","ancestors":["DOID:14566","DOID:5517","DOID:305","DOID:3119","DOID:0050686","DOID:10534","DOID:4","DOID:76","DOID:77","DOID:7","DOID:0050687","DOID:162","DOID:3717","DOID:299"],"children":[],"def":"","descendants":[],"doid":"DOID:10541","name":"microinvasive gastric cancer","parents":["DOID:3717"],"synonyms":{"exact":["early gastric cancer","Surface gastric cancer"]},"xrefs":{"ncit":"C27131","snomedct_us_2023_03_01":"276809004","umls_cui":"C0349530"}},"disgenet":{"_license":"https://creativecommons.org/licenses/by/4.0/","genes_related_to_disease":[{"DPI":0.885,"DSI":0.429,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":174,"gene_name":"AFP","pubmed":[29121872],"score":0.01,"source":"BEFREE"},{"DPI":0.962,"DSI":0.373,"EI":1.0,"YearFinal":2016,"YearInitial":2014,"gene_id":324,"gene_name":"APC","pubmed":[27514024,24272205],"score":0.02,"source":"BEFREE"},{"DPI":0.808,"DSI":0.502,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":387,"gene_name":"RHOA","pubmed":[28624843],"score":0.01,"source":"BEFREE"},{"DPI":0.923,"DSI":0.344,"EI":1.0,"YearFinal":2014,"YearInitial":2014,"gene_id":595,"gene_name":"CCND1","pubmed":[25202078],"score":0.01,"source":"BEFREE"},{"DPI":0.423,"DSI":0.666,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":618,"gene_name":"BCYRN1","pubmed":[29039538],"score":0.01,"source":"BEFREE"},{"DPI":0.731,"DSI":0.459,"EI":1.0,"YearFinal":2008,"YearInitial":2008,"gene_id":864,"gene_name":"RUNX3","pubmed":[18097595],"score":0.01,"source":"BEFREE"},{"DPI":0.962,"DSI":0.363,"EI":1.0,"YearFinal":2019,"YearInitial":2016,"gene_id":960,"gene_name":"CD44","pubmed":[27923017,30913874,25779358],"score":0.03,"source":"BEFREE"},{"DPI":0.808,"DSI":0.401,"EI":1.0,"YearFinal":2010,"YearInitial":2010,"gene_id":999,"gene_name":"CDH1","pubmed":[20063069],"score":0.01,"source":"BEFREE"},{"DPI":0.769,"DSI":0.458,"EI":1.0,"YearFinal":2019,"YearInitial":2019,"gene_id":1045,"gene_name":"CDX2","pubmed":[31354341],"score":0.01,"source":"BEFREE"},{"DPI":0.846,"DSI":0.42,"EI":1.0,"YearFinal":2018,"YearInitial":2017,"gene_id":1048,"gene_name":"CEACAM5","pubmed":[29121872,29742692],"score":0.02,"source":"BEFREE"},{"DPI":0.731,"DSI":0.494,"EI":1.0,"YearFinal":2018,"YearInitial":2017,"gene_id":1084,"gene_name":"CEACAM3","pubmed":[29121872,29742692],"score":0.02,"source":"BEFREE"},{"DPI":0.769,"DSI":0.494,"EI":1.0,"YearFinal":2018,"YearInitial":2017,"gene_id":1087,"gene_name":"CEACAM7","pubmed":[29121872,29742692],"score":0.02,"source":"BEFREE"},{"DPI":0.808,"DSI":0.446,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":1268,"gene_name":"CNR1","pubmed":[27271924],"score":0.01,"source":"BEFREE"},{"DPI":0.846,"DSI":0.4,"EI":1.0,"YearFinal":2018,"YearInitial":2018,"gene_id":1351,"gene_name":"COX8A","pubmed":[30128004],"score":0.01,"source":"BEFREE"},{"DPI":0.615,"DSI":0.558,"EI":1.0,"YearFinal":2012,"YearInitial":2012,"gene_id":1365,"gene_name":"CLDN3","pubmed":[22290341],"score":0.01,"source":"BEFREE"},{"DPI":0.808,"DSI":0.494,"EI":1.0,"YearFinal":2012,"YearInitial":2012,"gene_id":1366,"gene_name":"CLDN7","pubmed":[22290341],"score":0.01,"source":"BEFREE"},{"DPI":0.846,"DSI":0.488,"EI":1.0,"YearFinal":2018,"YearInitial":2018,"gene_id":1371,"gene_name":"CPOX","pubmed":[29425880],"score":0.01,"source":"BEFREE"},{"DPI":0.923,"DSI":0.328,"EI":1.0,"YearFinal":2005,"YearInitial":2005,"gene_id":1636,"gene_name":"ACE","pubmed":[16365022],"score":0.01,"source":"BEFREE"},{"DPI":0.885,"DSI":0.426,"EI":1.0,"YearFinal":2019,"YearInitial":2019,"gene_id":1666,"gene_name":"DECR1","pubmed":[31370714],"score":0.01,"source":"BEFREE"},{"DPI":0.885,"DSI":0.295,"EI":1.0,"YearFinal":2015,"YearInitial":2015,"gene_id":1956,"gene_name":"EGFR","pubmed":[25593477],"score":0.01,"source":"BEFREE"},{"DPI":0.923,"DSI":0.328,"EI":1.0,"YearFinal":2018,"YearInitial":2015,"gene_id":2064,"gene_name":"ERBB2","pubmed":[30120594,25593477],"score":0.02,"source":"BEFREE"},{"DPI":0.615,"DSI":0.656,"EI":1.0,"YearFinal":2019,"YearInitial":2017,"gene_id":2098,"gene_name":"ESD","pubmed":[31382963,30725253,28378078,30298447],"score":0.04,"source":"BEFREE"},{"DPI":0.692,"DSI":0.588,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":2168,"gene_name":"FABP1","pubmed":[27884752],"score":0.01,"source":"BEFREE"},{"DPI":0.846,"DSI":0.474,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":2194,"gene_name":"FASN","pubmed":[27884752],"score":0.01,"source":"BEFREE"},{"DPI":0.808,"DSI":0.485,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":2520,"gene_name":"GAST","pubmed":[28072871],"score":0.01,"source":"BEFREE"},{"DPI":0.808,"DSI":0.489,"EI":1.0,"YearFinal":2019,"YearInitial":2019,"gene_id":2744,"gene_name":"GLS","pubmed":[30485682],"score":0.01,"source":"BEFREE"},{"DPI":0.577,"DSI":0.686,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":3004,"gene_name":"GZMM","pubmed":[28977792],"score":0.01,"source":"BEFREE"},{"DPI":0.885,"DSI":0.374,"EI":1.0,"YearFinal":2017,"YearInitial":2017,"gene_id":3082,"gene_name":"HGF","pubmed":[28595915],"score":0.01,"source":"BEFREE"},{"DPI":0.769,"DSI":0.476,"EI":1.0,"YearFinal":2015,"YearInitial":2015,"gene_id":3490,"gene_name":"IGFBP7","pubmed":[26043748],"score":0.01,"source":"BEFREE"},{"DPI":0.923,"DSI":0.373,"EI":1.0,"YearFinal":2004,"YearInitial":2004,"gene_id":3557,"gene_name":"IL1RN","pubmed":[15570075],"score":0.01,"source":"BEFREE"},{"DPI":0.962,"DSI":0.248,"EI":1.0}]}}],"_note":"Response truncated for documentation purposes"}
curl --location --request GET 'https://zylalabs.com/api/4424/diseases+information+api/5437/disease?q=cancer' --header 'Authorization: Bearer YOUR_API_KEY'
To use this endpoint you must specify a Mondo ID in the parameter.
For example: MONDO:0011361
You will get this ID from the Disease endpoint.
{"_id":"MONDO:0011361","_version":1,"ctd":{"omim":"603688","pathway_related_to_disease":[{"inference_gene_symbol":"EPHB2","kegg_pathway_id":"hsa04360","pathway_name":"Axon guidance","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Developmental Biology","react_pathway_id":"R-HSA-1266738","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPH-Ephrin signaling","react_pathway_id":"R-HSA-2682334","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"L1CAM interactions","react_pathway_id":"R-HSA-373760","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPHB-mediated forward signaling","react_pathway_id":"R-HSA-3928662","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Ephrin signaling","react_pathway_id":"R-HSA-3928664","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"EPH-ephrin mediated repulsion of cells","react_pathway_id":"R-HSA-3928665","source":"CTD"},{"inference_gene_symbol":"EPHB2","pathway_name":"Axon guidance","react_pathway_id":"R-HSA-422475","source":"CTD"}]},"disgenet":{"_license":"https://creativecommons.org/licenses/by/4.0/","genes_related_to_disease":[{"DPI":0.846,"DSI":0.374,"gene_id":2048,"gene_name":"EPHB2","score":0.4,"source":"CLINVAR"},{"DPI":0.846,"DSI":0.374,"gene_id":2048,"gene_name":"EPHB2","score":0.4,"source":"CTD_human"}],"variants_related_to_disease":[{"DSI":1.0,"chrom":"1","pos":22907980,"rsid":"rs121912582","score":0.7,"source":"CLINVAR"},{"DPI":0.08,"DSI":0.882,"chrom":"1","pos":22913757,"rsid":"rs76826147","score":0.7,"source":"CLINVAR"}],"xrefs":{"disease_name":"PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding)","mondo":"MONDO:0011361","omim":"603688","umls":"C1863600"}},"hpo":{"disease_name":"Prostate cancer/brain cancer susceptibility","omim":"603688","phenotype_related_to_disease":[{"biocuration":{"date":"2013-01-14","name":"HPO:skoehler"},"evidence":"IEA","hpo_id":"HP:0100006","omim_refs":"OMIM:603688","original_disease_id":"OMIM:603688"},{"biocuration":{"date":"2013-01-09","name":"HPO:skoehler"},"evidence":"IEA","hpo_id":"HP:0012125","omim_refs":"OMIM:603688","original_disease_id":"OMIM:603688"}]},"mondo":{"ancestors":["MONDO:0003847","MONDO:0020573","MONDO:0023370","MONDO:0021058","MONDO:0700096","MONDO:0002254","MONDO:0045024","MONDO:0042489","MONDO:0015356","MONDO:0000001"],"excluded_subClassOf":{"mondo":["MONDO:0008315"]},"has_material_basis_in_germline_mutation_in":{"http":["http://identifiers.org/hgnc/3393"]},"label":"prostate cancer/brain cancer susceptibility","mondo":"MONDO:0011361","parents":["MONDO:0015356"],"predisposes_towards":{"mondo":["MONDO:0001657"]},"synonym":{"exact":["prostate cancer/brain cancer susceptibility","prostate cancer/brain cancer susceptibility, somatic"],"related":["Capb","Pcbc"]},"xrefs":{"medgen":["400334"],"omim":["603688"],"umls":["C1863600"]}}}
curl --location --request GET 'https://zylalabs.com/api/4424/diseases+information+api/5439/disease+by+id&ID=Required' --header 'Authorization: Bearer YOUR_API_KEY'
| Header | Description |
|---|---|
Authorization
|
[Required] Should be Bearer access_key. See "Your API Access Key" above when you are subscribed. |
No long-term commitment. Upgrade, downgrade, or cancel anytime. Free Trial includes up to 50 requests.
Diseases Information API provides structured data and information on various diseases, including genetic factors, associated genes, clinical manifestations and related pathways.
Zyla provides a wide range of integration methods for almost all programming languages. You can use these codes to integrate with your project as you need.
There are different plans to suit all tastes, including a free trial for a small number of requests, but your rate is limited to avoid abuse of the service.
This API is essential because it allows users to obtain detailed and up-to-date information on a wide range of diseases, including genetic data, associated genes, variants, clinical data and relevant pathways.
To use this API, users must indicate the name of a disease.
The GET Disease endpoint returns a list of diseases with associated genes, genetic variants, and clinical phenotypes. The GET Disease by ID endpoint provides detailed information about a specific disease, including pathways related to the disease and gene interactions.
Key fields include "_id" (disease identifier), "ctd" (data related to genes and pathways), "omim" (Online Mendelian Inheritance in Man ID), and "pathway_related_to_disease" (list of pathways linked to the disease).
The response data is structured in JSON format, with a top-level object containing metadata (like "took" and "total") and an array of "hits" that detail each disease's information, including associated genes and pathways.
The GET Disease endpoint provides disease names, associated genes, and genetic variants. The GET Disease by ID endpoint offers in-depth details about a specific disease, including pathways, gene interactions, and clinical data.
The GET Disease endpoint requires the disease name as a parameter, while the GET Disease by ID endpoint requires a specific Mondo ID. These parameters allow users to customize their queries for targeted information.
Users can analyze the returned data to identify genetic factors associated with diseases, support clinical decision-making, and inform research on disease mechanisms. The structured format allows for easy integration into applications.
The data is sourced from reputable biomedical databases, including the Comparative Toxicogenomics Database (CTD) and Online Mendelian Inheritance in Man (OMIM), ensuring high accuracy and reliability.
If the API returns partial or empty results, users should verify the input parameters for accuracy. Additionally, consider using broader search terms or checking for alternative disease names to improve result retrieval.
Please have a look at our Refund Policy: https://zylalabs.com/terms#refund
To obtain your API key, you first need to sign in to your account and subscribe to the API you want to use. Once subscribed, go to your Profile, open the Subscription section, and select the specific API. Your API key will be available there and can be used to authenticate your requests.
You can’t switch APIs during the free trial. If you subscribe to a different API, your trial will end and the new subscription will start as a paid plan.
If you don’t cancel before the 7th day, your free trial will end automatically and your subscription will switch to a paid plan under the same plan you originally subscribed to, meaning you will be charged and gain access to the API calls included in that plan.
The free trial ends when you reach 50 API requests or after 7 days, whichever comes first.
No, the free trial is available only once, so we recommend using it on the API that interests you the most. Most of our APIs offer a free trial, but some may not include this option.
Yes, we offer a 7-day free trial that allows you to make up to 50 API calls at no cost, so you can test our APIs without any commitment.
Zyla API Hub is like a big store for APIs, where you can find thousands of them all in one place. We also offer dedicated support and real-time monitoring of all APIs. Once you sign up, you can pick and choose which APIs you want to use. Just remember, each API needs its own subscription. But if you subscribe to multiple ones, you'll use the same key for all of them, making things easier for you.
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